Painful sex and vaginal dryness after menopause
FDA-approvedCan DHEA Supplements Help Your Energy Levels and More?
DHEA can help some women in specific situations. It is a hormone, not a vitamin: your adrenal glands make it, your body turns it into testosterone and estrogen, and levels fall steadily from your late 20s. Replacing it helps when the adrenals can't make enough, and a vaginal form is FDA-approved for painful sex after menopause. For energy in otherwise healthy women, the evidence is thin.
What DHEA can and can't do.
Evidence mapLibido
Modest, mixedMood
ModestBone
MixedWhat is DHEA?
Dehydroepiandrosterone, DHEA, is made mostly by the adrenal glands and in smaller amounts by the ovaries.
It is a precursor: on its own it does little, but the body converts it into testosterone and estrogens.
Its circulating form, DHEA-S, is what a blood test measures.
Levels peak around age 25 and fall by roughly half by 50 and further after that, which is why DHEA is marketed as an "anti-aging" supplement.
Falling DHEA is normal; it isn't a deficiency disease.
Does DHEA give you energy?
For most women, no.
The strongest evidence is in adrenal insufficiency, where the glands make too little of everything and replacing DHEA improves wellbeing and mood. In healthy adults whose levels are lower with age, trials of oral DHEA show little or no change in energy, strength or thinking.
If fatigue is your main complaint in your 40s or 50s, the more likely causes are perimenopause itself (poor sleep from night sweats, mood changes), thyroid, iron, and vitamin D, all of which are easy to test. Our guides to low thyroid and perimenopause symptoms cover the pattern.
What DHEA supplements can help with
Painful sex and vaginal dryness after menopause
FDA-approvedA low-dose vaginal DHEA insert (prasterone) is FDA-approved for this. It acts locally, with very little rise in hormones elsewhere in the body, and it is an option for women who can't or don't want to use estrogen.
Libido
Modest, mixedSome trials in women with low DHEA-S show modest improvement in desire; others show none. Testosterone itself, prescribed and monitored, is better studied for this.
Mood
ModestSmall studies suggest a modest effect in midlife women with low mood, mainly when DHEA-S is low. It is not a treatment for depression.
Bone
MixedMixed. Some trials in older women show small gains in bone density; guidelines don't recommend it for bone.
What DHEA does not do
DHEA has not been shown to cause weight loss, prevent heart disease, treat or prevent diabetes, boost immunity or prevent dementia. Some studies have found it can lower HDL ("good") cholesterol.
Side effects
Because DHEA becomes testosterone and estrogen, the side effects are hormonal:
These are more likely at the doses sold over the counter (often 25–50 mg, well above what most women would need) and more likely without a blood level to guide them.
Who should not take DHEA
Test before you take it
A DHEA-S blood test, often alongside testosterone and estradiol, shows whether you are actually low and gives a baseline to check against.
At Golden Leaf Health, DHEA is treated as a hormone. If a provider thinks it may help, it is prescribed at a dose chosen for you and rechecked, not picked off a shelf. Supplements and hormones are part of a plan built on your visit and symptoms.
If you'd like your energy, mood or libido looked at as a whole,
Questions, answered plainly.
What does DHEA do?
DHEA is a hormone made by the adrenal glands that the body converts into testosterone and estrogen. Levels peak in your 20s and fall steadily with age. It is sold as a supplement in the US, but it behaves like a hormone, not a vitamin.
Does DHEA give you energy?
Not reliably. In people whose adrenal glands don't make enough DHEA, replacing it improves wellbeing. In healthy adults whose levels are simply lower with age, trials show little or no effect on energy. If fatigue is your main symptom, thyroid, iron, sleep and perimenopause itself are more likely causes.
What are the benefits of DHEA supplements?
The clearest benefit is for painful sex after menopause, using a vaginal DHEA prescription called prasterone, which is FDA-approved. Oral DHEA has modest evidence for libido and mood in some women and mixed evidence for bone. Claims about weight loss, heart disease, diabetes and immunity are not supported.
Should I take DHEA without testing?
No. Because DHEA converts to testosterone and estrogen, a dose that is right for one person can cause acne, hair growth or mood changes in another. A DHEA-S blood test shows whether you are low; your provider can then decide whether to use it and how much.
Who should not take DHEA?
Anyone with a history of hormone-sensitive cancer, liver disease or PCOS, anyone already taking testosterone, and anyone pregnant. Tell your provider about mood or psychiatric medications before starting it.



