JournalHormone imbalance

5 Ways to Beat PMS and Signs of Hormonal Imbalance

Irritable, bloated, crampy or anxious before your period? Five ways to ease PMS and signs of hormonal imbalance: estrogen clearance, inflammation, magnesium, xenoestrogens and progesterone.

5 Ways to Beat PMS and Signs of Hormonal Imbalance3 min read

Irritable? Drained? Anxious? Bloated, crampy, or gaining weight for no clear reason? These are classic PMS symptoms, and they are also common signs of hormonal imbalance. They can change how you feel about yourself and the people around you for a week or two every month.

Why PMS often points to estrogen dominance

Many of these symptoms trace back to estrogen dominance: estrogen that isn’t balanced by enough progesterone. Estrogen on its own can increase inflammation, irritability and anxiety. Progesterone is the calming counterweight. It relaxes smooth muscle, eases bloating and cramps, settles the nervous system, and acts as a mild diuretic, so it reduces fluid retention.

When your body doesn’t make enough progesterone to balance the estrogen it produces, plus any xenoestrogens (estrogen-like chemicals from the environment), the estrogen effects win. That is what “estrogen dominance” describes. It is common in the late reproductive years and in perimenopause, when ovulation becomes irregular and progesterone drops first.

Here are five ways to ease PMS and other signs of hormonal imbalance, from everyday habits to prescription options.

1. Help your body clear estrogen

After estrogen has done its job, the liver breaks it down and sends it out through bile into the stool. If you aren’t having regular, complete bowel movements, some of that estrogen can be reabsorbed, adding to estrogen dominance symptoms. Fiber, water and a healthy gut microbiome all support this process. Our post on estrogen metabolism explains the three phases in more detail.

Two nutrients are often used to support estrogen clearance:

  • Calcium D-glucarate helps block beta-glucuronidase, an enzyme in the gut that can free estrogen from bile so it is reabsorbed. It supports the liver’s phase II detoxification pathway.
  • DIM (diindolylmethane), a compound derived from broccoli and other cruciferous vegetables, encourages estrogen to break down along the more favorable 2-hydroxy pathway.

Supplements are optional and not right for everyone. Talk with your provider before starting them, especially if you take other medications.

2. Reduce inflammation

Inflammation makes cramps, breast tenderness and low mood worse. Over-the-counter anti-inflammatories like ibuprofen help some women in the short term. Nutrition-based options that may help over time include:

  • Curcumin and resveratrol. Both have antioxidant and anti-inflammatory properties, and resveratrol, like DIM, may support healthier estrogen breakdown.
  • Omega-3 fatty acids (EPA and DHA) from fatty fish or fish oil, which can reduce inflammation and may support mood.

3. Relax muscles and nerves with magnesium and B vitamins

Magnesium takes part in more than 300 enzyme reactions in the body, and many people don’t get enough. Alcohol, a high-salt diet, phosphoric acid in sodas, and chronic stress all lower magnesium. Magnesium can ease cramps, headaches and anxiety, and help with sleep. Food sources include nuts, beans, dark chocolate, leafy greens and whole grains.

Vitamin B1 (thiamine) and vitamin B6 have both been studied for PMS. B1 may help with cramping, and B6 may help with mood symptoms. Discuss dosing with a qualified provider; more is not better with B6.

4. Cut down on xenoestrogens

Xenoestrogens are chemicals that act like estrogen in the body and can disrupt hormone balance. Common sources are plastics, fragrances and some personal-care and cleaning products. Practical swaps:

  • Choose fragrance-free skin and hair products without phthalates or parabens.
  • Store and heat food in glass rather than plastic.
  • Use simpler, lower-toxin cleaning products.

You can’t avoid every exposure, but reducing the daily load helps.

5. Balance your hormones with a provider

If lifestyle changes and supplements aren’t enough, a provider can look at the hormones themselves. Hormone testing can show whether low progesterone, high estrogen or something else, such as thyroid, is behind your symptoms. Where appropriate, a clinician can prescribe bioidentical progesterone, which can ease anxiety and cramps, balance estrogen and improve sleep. Like any hormone therapy, it has benefits and risks that your provider will review with you. Learn more about bioidentical hormone replacement therapy.

When to get help

PMS is common, but it isn’t something you have to put up with. If symptoms disrupt work, relationships or sleep every month, or if they are getting worse as you approach your forties, talk with a provider. Our care team sees patients by video in 33 states. Call (760) 542-8898 or book your first visit.


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This is general information, not medical advice. Talk with your provider about your health and treatment options.